You can run OneDrive with a logon script and apply it to your users via a GPO.

Here is the FAQ regarding how to create a logon script :

Per example, we have added OneDrive and the Notepad to the logon script and both launch from the Application Portal when the user connects :


In the script all you need to do is add the path of the OneDrive exe in a text file that is named OneDrive.bat.

In our case, we added "C:\Program Files\Microsoft OneDrive\Onedrive.exe"

And added it like this: